The post holder will perform research investigating the role of exosomes in vascular smooth muscle cell (VSMC) biology. Exosomes are novel intercellular messengers yet their patho-physiological significance remains unknown. Phenotypically modulated VSMCs secrete exosomes that instigate vascular calcification. This project will examine the signalling pathways that link phenotypic modulation to exosome secretion focussing on the cytoskeleton, extracellular matrix (ECM) as well as sphingomyelin/ceramide pathway mediators. It will also examine how exosome secretion is linked to VSMC migration, proliferation and ECM remodelling and hence vascular pathology. The candidate should have experience in exosome biology including isolation, quantification and characterisation by flow cytometry. Experience in Confocal and Super-resolution microscopy as well as image analysis is highly desireable. The successful candidate will join a research group within the BHF Centre of Research Excellence which provides an excellent highly multidisciplinary environment with state-of-the-art equipment and facilities.